Dana Delany is introduced in the role of Katherine Mayfair, whose mysterious arc is the season's main storyline.Five out of six actors who received "also starring" billing from the previous season returned.
Filming for the series was interrupted by the 2007-2008 Writers Guild of America strike in November 2007, after production on the two-episode tornado storyline wrapped.
Shawn Pyfrom, portrayed Bree's homosexual son Andrew Van de Kamp.
Lyndsy Fonseca was cast in the new role of Dylan Mayfair, Katherine's daughter and part of the season's mystery.
Joy Lauren reappeared in the role of Danielle Van de Kamp, Bree's pregnant daughter.
Brent Kinsman, Shane Kinsman and Zane Huett, played Preston Scavo, Porter Scavo and Parker Scavo, Lynette's troublesome children.